Journal article
Amygdala activation and symptom dimensions in obsessive-compulsive disorder
E Via, N Cardoner, J Pujol, P Alonso, M López-Solà, E Real, O Contreras-Rodríguez, J Deus, C Segalàs, JM Menchón, C Soriano-Mas, BJ Harrison
British Journal of Psychiatry | CAMBRIDGE UNIV PRESS | Published : 2014
Abstract
Background Despite knowledge of amygdala involvement in fear and anxiety, its contribution to the pathophysiology of obsessive-compulsive disorder (OCD) remains controversial. In the context of neuroimaging studies, it seems likely that the heterogeneity of the disorder might have contributed to a lack of consistent findings. Aims To assess the influence of OCD symptom dimensions on amygdala responses to a well-validated emotional facematching paradigm. Method Cross-sectional functional magnetic resonance imaging (fMRI) study of 67 patients with OCD and 67 age-, gender- and education-level matched healthy controls. Results The severity of aggression/checking and sexual/religious symptom dime..
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Grants
Awarded by Carlos III Health Institute
Awarded by Agency of University and Research Funding Management of the Catalan Government AGAUR
Awarded by Beatriu de Pinos Modalitat-A fellowship awarded by AGAUR
Awarded by Miguel Servet contract from the Carlos III Health Institute
Awarded by National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award
Funding Acknowledgements
This study was supported in part by the Carlos III Health Institute (PI05/0884, PI07/1029, PI09/01331, PI10/01753, PI10/01003, CP10/00604 and CIBER-CB06/03/0034) and by the Agency of University and Research Funding Management of the Catalan Government (AGAUR; 2009SGR1554 and 2009SGR1450). M.L.-S. is supported by a Beatriu de Pinos Modalitat-A fellowship awarded by AGAUR (fellowship number: 2010 BP_A 00136). ER. Is supported by a Rio Hortega contract from the Carlos III Health Institute (ID. CM11/000771. C.S.-M. is funded by a Miguel Servet contract from the Carlos III Health Institute (CP10/00604). B.J.H is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Award (IA 628509).